Genetic heterozygosity in pneumococcal transformation.

Genetic Studies of Recombining DNA in Pneumococcal Transformation

The results of genetic fine structure experiments, performed on the amiA locus of Pneumococcus are summarized. The peculiar feature of transformation genetics is that a given donor marker mutation transforms with an efficiency characteristic of the mutated site. In spite of this difficulty, mapping procedures have been devised and quantitative recombination studies performed. It is concluded fr...

Genetic Studies of Recombining DNA h Pneumococcal Transformation

A B s TR AC T The results of genetic fine structure experiments, performed on the amiA locus of Pneumococcus are summarized. The peculiar feature of transformation genetics is that a given donor marker mutation transforms with an efficiency characteristic of the mutated site. In spite of this difficulty, mapping procedures have been devised and quantitative recombination studies performed. It i...

Transformation of Pneumococcal in Vitro

Heterozygosity and Genetic Distance

In the mid-1960s protein electrophoresis revolutionized the study of population genetics and evolution. This technique revealed an extensive amount of genetic polymorphism existing in natural populations and, at the same time, provided a powerful tool to examine the evolutionary relationships of closely related species.1’2 In 1972 I developed a statistical method by which one can measure the ge...

Pneumococcal Transformation -A Backward View